Study type
Select the type of study you think this document is reporting.
Any good
Select Yes if you think the record is describing an RCT and there looks to be enough information about the participants and the intervention.
Sex of participants
Did the trial aim to include both male and female participants?. If yes, select Male and Female.
If the abstract doesn’t specify, and the participants could be either male or female (i.e. not a study in pregnant women), select Male and Female.
Age of participants
If the age of the participants is not reported (and it often isn't), select not reported. If the abstract just says "children", then select the Child age category. Similarly, if it says "adults" then select the Adult age category.
Health condition
We want to know what the health condition of the participants was. We’re using controlled vocabularies to help reduce the potential for typing errors and increase consistency of annotations between abstracts.
If you can’t find the term you are looking for, select No available term, and copy and paste the term you were looking for into the Notes field.
Country
If the country where the study took place is reported, start typing it in the box and select the right country from the pick list.
Number of participants
Type the number of participants in digits (not words). If the total number is not reported you can enter two or more numbers separated by a plus sign in the box and the numbers will be added up for you, e.g. 24+41 [press return] and the number in the box will change to 65.
Intervention type
If the study was not an interventional study, select Not applicable. If it was, for each intervention used, select a high level intervention type classification from the pick list, and then the specific intervention from the type ahead box that will appear once a classification has been made.
There are 15 high level classifications to choose from:
Behavioral: an intervention designed to affect the actions people take with regard to their health, e.g. a weight reduction regimen
Cellular and Gene: interventions that are targeted at a cellular or gene level, e.g. stem cell therapy
Complementary: interventions that are not conventional but might be used alongside other treatments e.g. acupuncture
Complex: interventions that have a number of interacting components
Educational: interventions based on teaching and learning, e.g. skills training
Medical Devices: interventions based on medical or health related equipment, e.g. mobility aids
No active intervention: interventions that will not have an effect (or will have as little effect as possible) such as a placebo
Pharmacological: drug-based interventions (this includes nutritional supplements)
Physical: interventions that involve physical activity, e.g. physiotherapy
Psychological: interventions that involve changing thinking patterns
Radiotherapy: interventions based on using high-energy rays, e.g. x-rays or ultrasound
Resources and Infrastructure: these are interventions that involve a re-organisation of health care provision or training of health care professionals
Screening: these kinds of interventions are aimed at identifying the possible presence of a disease that has not yet been diagnosed in those who are not shows any signs or symptoms of the disease yet
Surgical: interventions such as organ and bone marrow transplantation, tissue grafts and transfusions
Vaccines: interventions that involve a vaccine - a biological preparation that improves immunity to a particular disease
When you use the type ahead to find the specific intervention that was used, you might see a number against that intervention. That number indicates how many time that term has been used already.
Comparator
If the study didn’t use a comparator, select Not applicable
If the study used a placebo as a comparator, select No active treatment from the high level classifications list and then use the type ahead to find placebo.
Outcome type
We have a high-level classifications scheme for outcome types. For each outcome, select a high-level classification and type the specific outcome that was measured.
Outcome
We want to know each of the outcomes reported in the abstract. For each outcome we want a high level classification, and, some free text copied from the abstract about the specific outcome. For example, if the outcome is cognition, select Physiological or clinical from the pick list and copy and paste cognition into the free text box that will appear. For more information on outcomes, take a look at the Quick Ref guide accessible from the task dashboard.
Not applicable
Select Not applicable when the question is not applicable to the study type.
Not reported
It is quite likely that some items might not be reported in the abstract. When this is the case use the Not Reported radio button.
No available term
Sometimes there will not be a controlled vocabulary term to describe a health condition or and intervention or comparator. If you cannot find the term you would like to use, select, No available term radio button.
Not applicable
Select Not applicable when the question is not applicable to the study type
Relevant antidepressants
Second generation antidepressants are a class of drugs used to treat depressive disorders. There are quite a lot of second-generation antidepressants. The ones we’re interested in for this review are:
- Bupropion
- Citalopram
- Desvenlafaxine
- Duloxetine
- Fluoxetine
- Escitalopram
- Fluvoxamine
- Levomilnacipran
- Mirtazapine
- Nefazodone
- Paroxetine
- Sertraline
- Trazodone
- Venlafaxine
- Vilazodone
- Vortioxetine
